Synthetic Studies Toward Substituted Benzene, Quinoline, Indoloquinoline Derivatives from Bromovinylaldehydes and Stereoselective Synthesis of Tricyclic Thiophene Derivatives Use of transition metal compounds or complexes as catalysts or reagents in organic synthesis is an exciting field in research and numerous novel reactions which are impossible to achieve by conventional synthetic methods have already been discovered. Total syntheses of tetra substituted benzene derivatives having 5,6- position free is very important structural motif present in many important class of compounds. Synthesis of benzene derivatives will be difficult, because of orientational problem associated with functional groups present or introduced in the benzene ring. Although Diels Alder reaction seems to be good, but cyclo trimerisation of alkynes will not be feasible so far as selectivity is concerned. So, undertaking a synthetic project from readily obtainable β-bromovinylaldehydes seems to be worthy. We have also used β-bromovinylaldehydes for the synthesis of quinoline and indoloquinoline derivatives. Finally tricyclic thiophene derivatives are non-natural. However, corresponding furo and phenyl derivatives are important class of natural terpenes of biological importance. Syntheses of tricyclic thiophene derivatives by radical and cationic cyclization methods have been attempted.
Surajit Some, Guide: J. K. Ray, DEPARTMENT OF CHEMISTRY, Indian Institute of Technology, Kharagpur, 2007